Modification of meta-iodobenzylguanidine uptake in neuroblastoma cells by elevated temperature
نویسندگان
چکیده
منابع مشابه
Accumulation of /w-Iodobenzylguanidine by Neuroblastoma Cells Results from Independent Uptake and Storage Mechanisms1
The modalities of uptake and storage of iodine-labeled m-iodobenzylguanidine (MIBG) by four human neuroblastoma cell lines have been studied. SK-N-BE(2)C cell line has been shown to possess the specific (type 1) MIBG uptake, as well as an efficient extravesicular storage mechanism. Conversely, LAN-5 cells, which show a nonsaturation kinetic of MIBG incorporation, lack only the ability to effici...
متن کاملActive uptake and extravesicular storage of m-iodobenzylguanidine in human neuroblastoma SK-N-SH cells.
Radio-iodinated m-iodobenzylguanidine (MIBG), an analogue of the neurotransmitter norepinephrine (NE), is increasingly used in the diagnosis and treatment of neural crest tumors. Active uptake and subsequent retention of MIBG and NE was studied in human neuroblastoma SK-N-SH cells. Neuron-specific uptake of [125I]MIBG and [3H]NE saturated at extracellular concentration of 10(-6) M and exceeded ...
متن کاملModification of growth of neuroblastoma cells in syngeneic mice by aldehyde-treated neuroblastoma cells.
Pretreatment of syngeneic strain A mice with aldehyde-fixed neuroblastoma cells (clone NB6R) almost completely protected the mice against challenge with viable NB6R cells. In contrast, tumor growth was enhanced in mice treated with fixed cells after challenge with viable cells.
متن کاملRadiosynthesis of no-carrier-added meta-[124I]iodobenzylguanidine for PET imaging of metastatic neuroblastoma
Meta-iodobenzylguanidine (mIBG) has been radiolabelled at the no-carrier-added level with [124I] for a proof of concept study to assess the diagnostic accuracy of [124I]mIBG PET/CT in detecting metastatic deposits in patients diagnosed with metastatic neuroblastoma. Radiolabelling of mIBG was achieved via the iododesilylation reaction between [124I]sodium iodide and meta-trimethylsilylbenzylgua...
متن کاملDevelopment of a Real-Time Polymerase Chain Reaction Assay for Prediction of the Uptake of Meta-[I]iodobenzylguanidine by Neuroblastoma Tumors
Purpose: The suitability of neuroblastoma patients for therapy using radiolabeled meta-iodobenzylguanidine (MIBG) is determined by scintigraphy after the administration of a tracer dose of radioiodinated MIBG whose uptake is dependent upon the cellular expression of the noradrenaline transporter (NAT). As a possible alternative to gamma camera imaging, we developed a novel molecular assay of NA...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1994
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1994.325